Re: His core gameplay approach won't change.
Geff has previously admitted he likes playing other rpg's so he can 'steal' ideas from them, yet he does this for financial gain as well as blogging to increase media contact/awareness to spiderweb games yet it still remains a fact Geff hates fantasy rpg's and hates himself for making them.
http://rpgvault.ign.com/articles/763/763050p1.html
So whatever new setting Geff may choose to use, by his own admission he is probably going to hate it.