Originally Posted by Yeesh 
Diablo II was released nine (9) frigging years ago, and it's yet to have a sequel or heir, official or otherwise.
In my opinion the point is simply this:
It dominates huge parts of the whole genre since then.
Just take a look at how many RPGs are having the word "action" in their desctription nowadays. None, if I see this correctly. Nowadays, ALL RPGs MUST have this attribute, or … well, at least marketing from all around the world believes it won't never ever sell.
That's a very subtle kind of domination, imho.