Originally Posted by Thrasher 
Example: I die, a load window pops up, I click on it. It takes almost a minute for the saved games list to come up!
Easy solution:
1. Locate your savegame folder. Should be in My Documents\The Witcher\Saves
2. move all but the newest 2 or 3 files somewhere else, or better yet, zip them all up. Or delete 90% of them. Savegames can be quite big (~20 MB) and get bigger the further in the game you are.
3. Voila. Savegame handling will be very quick again. Alternatively you can defrag your savegame directory. Or even your entire game directory, if you have the option (I used MyDefrag to put the entire game into one continuous piece of space on the disk, sorted by name … unnecessary with SDDs of course).