Originally Posted by Gorath 
I doesn't work with the nvidia drivers which supposedly fixed the issues?
Doh…! *facepalm*
That was the problem. I didn't realize the Forceware drivers I had installed were from last June. After downloading the newest set, Gothic 2 seems to being running fine.
The only problem I have now is trying to get it to run in widescreen. I was able to manually set the resolution to 1920x1200 in the Gothic.ini, but it resets back to 800x600 every time I restart the game.
*Edit* Solution is to change "extendedMenu=0" to "extendedMenu=1" in the Gothic.ini.