Originally Posted by JDR13 
I'm pretty sure gameplay balance most definitely has something to do with the overall difficulty.It doesn't make sense to claim otherwise. An augmentation that's overpowered is obviously going to give you more of an advantage than one that's not.
If you have a gameplay balanced for "people who play in the couch with a gamepad", the levels of difficulty won't change that fact. It can make it harder, but it still be a crappy game.
Originally Posted by JDR13 
I'm more concerned about the mission structure, and the amount of hand-holding involved.
That too.
Originally Posted by DoctorNarrative 
You mean mainstream gamers.
Yes, nowadays mainstream gamers, which means mostly they are console and mobile devices players. Not mainstream gamers from 10 years ago.
However that doesn't mean that all console players are mainstream gamers.