Originally Posted by DArtagnan 
Hand-painted style with that level of detail takes a huge amount of work to animate with any detail. I've seen it used in other games - and it invariably results in a few cells for each animation.
Unless, of course, they chose that style because they wanted a major workload - and not because they wanted to make it economically feasible to pull off.
I think it's visually jarring and I think it meshes very poorly with the Cyberpunk backdrop - based on the screenshot. Almost like having cartoon characters in a dystopian setting.
Not only fewer cells in animation. But probably characters that dont change related to the equipment they are wearing.
How much I love 2D animation (i am 2d animator myself) i think they would be better off making 3d animation that just looks like hand painted.