I have found someone having a similar issue : http://forums.ddo.com/showthread.php?p=4672294

I'm still using Windows XP, and my new card (the other one went kaputt - very likely (I fear) caused by DDO as well, possibly from overheating) is an 8600 GT based card - thge old one was a 9600 GT based card, both NVidia based.

However, I cannot start DDO anymore. At the loading screen it all freezes.
Even after resetting all settings from the Launcher program (taskbar -> right click -> options).

The OS generated a crash report, from which I saved some data before it got sent to Microsoft (you know, this usual crashing report dialog).

I'm simply stopping to play DDO from now on until I get this resolved. I just don't want to lose another graphics card.