Originally Posted by badmofo 
Yeah the save system isn't so bad, after some initial confusion because you're "on a mission" for a while at the start, it's simply a case of "checkpoints during missions, save anywhere otherwise". Like dartagnan said, you can save anywhere, but you still re-start from the closest checkpoint (safe house, etc) if you die or reload.
I still need a clarification…
If I start a mission, kill a few mobs, save the game then die and gameload puts me in the last "safe zone" - does the whole mission also reset so I have to kill the same ol' mobs all over again like I'm in generic lousy jRPG or they're dead for the rest of my (and their) life?