Haven't had a single bug in Skyrim yet except for grapical glitches that also were apparent FO:NV, overall FO:NV was buggier, but still havent finished Skyrim so i guess that could change.

One mistake i always do is fiddle way too much with the .ini files, following guides were people are doing mostly guesswork of how the values in the files work, it usually makes the game really unstable. For Skyrim a lot of people advice you to disable v-sync for example, which leads to numerous bugs..