Originally Posted by txa1265 
I took one piece of advice and turned HDR completely off, and after wasting an hour screwing around with crashing and reloading I got an hour of actual gameplay …
I have already turned all the setting down to medium (and a number of other tweaks) and was still getting CTD. I will give this turning off of the HDR a try and see if that does not stabilize the damned thing.
I just hope I can get it running before NWN2 shows up, cause I know I will be dropping of the edge of the earth for a while after it does!