Players who refuse to use implants will be at a definite disadvantage, but they will have access to a couple of high level skills towards the end of the game that are off-limits to cybernetic characters.
There's your dilemma then… short term gain or long term gain.
Woohoo.
Oh, and "Ewww, you're half a robot! Would you like a quest?" vs "Hey there Mr Manly man. Would you like a quest?" conversations.