This is what I've found with the key bindings
Character menu key = exit menu key
Switch POV = Set Favorite in inventory
Tab key = exit menu key
Enter = Use/consume (can't be bound to Set favorite, or you will consume that rare potion when you're trying to favorite it)
R key = take everything when looting, drop item in inventory.
These might not be exactly right, it's hard to keep track of. I use a Belkin Nostromo (gaming keyboard with enough keys for just left hand). The advantage is two keys can perform more than one function, if set up correctly, and save on button real estate. I have my R key set to 'ready weapons' and it also takes all when looting or drops an item from my bag. But it's still a mess straight out of the box (or rather the download queue)
More here but rather NSFW site
http://www.nakedskins.com/skyrim-nude-skins.shtml
I like the favorites menu, it pauses the game and you can easily grab things you use the most, or set number keys. Once you get used to having number keys bound to various weapons and spells (and potions if you like), it's easy to bring up various combinations of spells and weapons. Hitting 1 and 5 gives me a mace and a sparks spell or hitting 2 gives me the bow. Hitting 1 twice and I'm dual wielding two maces then just hit 5 once and I lose one mace and get the spell back. Or hit 6 and the spell switches to heal. Hit 6 twice and now two heal spells for more power etc. Kind of powerful system.
I've gotten used to the interface and the game is overall a massive improvement over Oblivion, reminding me of some of my favorite open world games (Gothic series, Two World 1) with great exploration, which is to me the MOST important aspect of open world RPGs. I hope it stays this good.
The mouse is fine in game (and I've made some tweaks especially dealing with odd difference in X vs Y sensitivities) but mediocre in menus, and in my experience can't be adjusted. Yes keyboard control is possible but the mouse should be easier to control in a PC.