Another back-on-topic post: I just tried Vampire: Bloodlines, encountered, and solved a problem.
Problem:
On Windows Vista x64 SP1 with an nVidia card and more than 3GB RAM, VtM:B will use lowest-resolution textures. IOW, it'll look like utter rubbish.
Workaround:
Run msconfig from the search box in the Start menu. Go to the Boot tab, hit the Advanced Options button, check the Maximum Memory box, enter 3072 into the box, and reboot.
Don't forget to un-check the box (and reboot) when you're done with Bloodlines; until then, that extra gig of RAM will be sitting in your box doing nothing.
There's another solution known, but it involves patching the executable with a hex editor, so I didn't try it.