Wow, lots of different opinions in this thread. My 2 cents:
First of all, it should be clear that although all of those games could be called shooter/RPGs, they are very different from each other.
1. In terms of
gameplay System Shock 2,
Deus Ex and
Bloodlines are still unique and unsurpassed, and my favorites in that order (Bloodlines being the best). Each felt like an iteration in the right direction to me. All of them offer distinct paths through the game, e.g. brute-force, hacking, sneaking or talking, as well as interesting and
meaningful skill systems and upgrade options.
None of the other listed games offered that.
2.
Stalker is a
free-roaming, atmospheric shooter with lots of quests and some other RPG mechanics that I don't remember too well.
3.
Mass Effect 1+2 are
dialog-based action adventure shooters with basic RPG elements. Due to their incredible, interactive cinematic presentation, particularly in case of ME2, some even consider them to be RPGs ...
4.
Fallout 3, Borderlands and Boiling Point I didn't play, so I can't comment.
5. I
think I played
No One Lives Forever 2 once, but from what I remember, even though it did have a skill system like the one shown in JemyM's screenshot, it didn't come close to Deus Ex (which I would compare it to) because it was very linear. No using your environment (hacking), sneaking past an entire section of the map or talking your way out of things. I could be wrong though. Still, I'm fine with it not being listed.
6.
Bioshock was a straight, if very atmospheric shooter. No RPG elements whatsoever, as far as I'm concerned. Like Doom 3 with a few more upgrades, nothing noteworthy though. A great game in its own right, but I'm happy it wasn't included in this poll.
So yeah, my vote went to Bloodlines for reasons written above. Perfect gameplay options. I so wish there'd be more games like the ones mentioned in 1.