Diablo 3 - Video Interview @ Gamestar

German site Gamestar has interviewed Leonard Boyarsky on Diablo III.  You can watch the English video here or Diablo III fansite diii.net has a transcription:

Leonard: The synergy is basically emphasized with more than just one skill. That’s what we are basically doing with the rune system. And basically what it is you get random drops which was kind of like in first Diablo. We really wanted to get that random skill feeling back, without actually doing random skills. So you get these random drops and you can slot them in different skills, different spells, and they’re removable so it’s not like you’re stuck with it. You know, the fun of just touching the different realms of what they do.