Borderlands 2 - Comedy in Games

VG247 talks with Borderlands 2 writer Anthony Burch in a video interview about writing comedy in games:

With games becoming more comedic, Sam Clay asked the lead writer of Borderlands 2, Anthony Burch, what his thoughts were on the subject. How difficult is it to write comedy for games? Easier than a stand-up comedian?

Borderlands’ tongue-in-cheek comedy could be compared in humour to a stand-up comedian’s gags or a radio sketch. How’s it done? What’s the key to making the player laugh? And what actually is funny in a video game?