CTD stops me progressing in HoS.
 

Can't get past the long cutscene with Shani after the wedding (Midnight Clear subquest). Game freezes at some point during the boat ride and CTDs as soon as the cutscene ends.

EDIT - apparently quite a few people with 7 series GTX cards experience the same problem…

EDIT 2 - turning all postprocessing off and spamming spacebar through the WHOLE (boat ride and beach) cutscene worked for me.