When we say that Shepard can die in Mass Effect 2, it’s not something that happens at points in the middle of the game. Yes, you can “die” in gameplay as normal but that’s not what we’re talking about here. It’s not a “Game Over” screen. It’s not a gimmicky thing where you make a choice, “die”, and reload to continue to the “real” ending. When you get to the very end of the story in Mass Effect 2, you will get one of a wide variety of climactic and satisfying endings. Depending on how prepared you were, your ending may involve Shepard making the ultimate sacrifice to accomplish the mission.