Nudity mods:
As far as graphics go, I just porn my game up with nude females, skimpy armor and/or clothing. I don't mess with lighting or FOV, though I generally load up anything that increases weather effects. I'll probably get into the settlement mods once I finish the main quest.
One fun thing for the porn enthusiasts is the variety of body suits in Fallout 4. You have road leathers, raider leathers, vault suits, etc. Each of these images can be swapped with the meshes from the various body mods so that you have a great variety in nude models. I assume that the male models will eventually catch up too, so the gals and gays will have their day too.
In Fallout 3, you'd have one set of chest/privates for every female or perhaps two if you changed raider females. If Fallout 4, you can have dozens and somebody will package this idea up one of these days so that it is a single install.