Hurls,
I have had wrist issues for ~15 years. Drs can never determine what is wrong - when they hear I play video games, they attribute it to permanent damage from repetitive stress disorder and stop helping. Stupidly took a flyer on one surgery that I think just made that wrist weaker. I have found that gamepad games are definitely better than mouse and keyboard. I still play lots of M/K, regardless. I wear carpal tunnel gloves 100% of the time I use the computer.
I would love to hear more thoughts about the steam controller and whether anyone can use it as replacement for K/M - I have enjoyed using an Xbox One controller in many games. I own a Steam controller because I thought it might help, but I have barely used it...
Hurls, it seems to me there are only a few different fundamental types of rpgs - (a) first or third person twitch based, which it sounds like you don't want - I still play those a lot, (b) overhead or isometric turn based which you want a break from, and (c) blobber type turn based first person, for which you mostly have to look to the past, but there are few new ones. I agree with Wiz 8 and MM6-8 if you haven't played them. By the time you get through all those, you will want to go back to overhead!