Well....... are you gonna tell us which mods you're using or not?
Certainly;
No Persistent Enchantment Glow. So you're not constantly glowing from wearing enchanted armour. Essential.
Chase Camera Mod. Makes the chase camera act like it does in Morrowind and I edited it so you can only zoom out as far as the camera does in Morrowind. That stops it zooming right out whenever you sit down, stand up, mount/dismount your horse ect. Also essential.
Deadlier Traps. Makes the booby traps in caves instantly fatal, not essential but I like it.
Level Slow. Slows down the rate you gain a level from between one and four times. I use x3. Essential and oh how I wish I could use something like this for Fallout 3 on the 360.
MCalebs Decompose Corpse. Handy to remove the clutter of dead bandits and stuff since they're too heavy to just pick up like you can in Fallout 3 (and make little piles).
Not Enough Charge. Stops the annoying "your enchanted weapon doesn't have enough charge" message.
My Fighter's Guild Chests. Adds a player safe chest and player only bed in each fighter's guild hall and DB sanctuary. And allows the player to use that one bed on the ground floor in Anvil that would be perfect for the player but actually belongs to Azan.
My House For Sale Revamp. Adds a few more decorations and another shelf and chest in the shack in the Imperial City.
No Quest Items. So you can drop quest items.
Respawn Timer Changer. So you can edit how quickly dungeons respawn. I always found it silly that a day after I'd cleaned a place out everything came back to life.
Natural Wildlife. Makes animals not automatically attack you.
Unoffical Equipment Rarity Patch. Makes valuable loot (like high end weapons and armour) much, much rarer. Very austere, but now you'll never, EVER see a bandit wearing elven, ebony or daedric armour. Essential.
Unoffical Mod Variety Generation. Mixes up the creatures in dungeons so they're not always the ones most appropriate to your level.
One that I forget what it's called but it removes the quest marker from the compass and makes all the items in the inventory smaller.
And my own No Deliver the Amulet Journal Entries. I made this because I wanted to start a new game without going through the opening dungeon and where I wasn't "the chosen one". I found a couple of alternate start mods but they weren't quite what I wanted. Making my own alternate start mod was a bit beyond me, so I just fast travel from the sewer to the docks of Anvil and, ahem... pretend my game's starting right there. And the journal doesn't mention anything about the Amulet of Kings. Instead it assumes I've just escaped a slave ship and washed up at the docks in Anvil. It also locks the door to Weynon Priory, cutting off the main quest completely.
Oh and I also edited the Mehrunes Razor DLC to remove the enchantment. I didn't like the disintergrate armour enchantment using up the charge all the time. I tried to just remove that one but it didn't work so I removed both. Now it's just an extremely wicked looking, big daedric dagger and I love it. Very good if you use the equipment rarity patch which is so austere you'll basically never find an actual daedric dagger.
And that's about it.