Pretty decent and relatively long video preview. I liked hearing that weapon mods do change the physical appearance of the weapons.
I was also happy when they reassured us that reputation trumps karma. It makes sense particularly when most realistic villains are those who do not view themselves as evil- so why would they only agree to work with a baby-eating klepto right? In one of the G4TV videos it was mentioned that instead of karma pre-requisites for certain quests that they use reputation instead. The idea being that people would offer you a sensitive and personally important quest because you have a reputation for "getting the job done" rather than because they evaluated the quality of your soul.
