PCGamer has a list of the best cities in PC gaming.
More information.Hell's Kitchen, from Deus Ex
As a series, Deus Ex has plenty of cities to choose from. Mankind Divided has Prague; Human Revolution has Detroit and Hengsha; and Invisible War made an attempt at Seattle, bless it forever. But only the original, ugly as it is, really captured the scale of a city. Its version of the Hell's Kitchen district of New York feels ominous and towering, sure, but, in comparison to the latter games, also spacious. Its streets are wide, making JC Denton feel like a small part of this huge place. Lots of games struggle with scale, but Deus Ex really captures the sense of a city's size.
Sure, it's not the most remarkable looking of the Deus Ex series' cities, and its backing music isn't as memorable as Hong Kong, but it feels like a real place. It's dark, dingy, and covered in recognisable detritus. As interesting as the paradoxically more futuristic cities of the prequels look, I appreciate how the familiarity of Hell's Kitchen serves to heighten what's different about the world. Plus, it's got a great bar. That's about 90% of the requirements of a great videogame city right there.
-Phil Savage