PC Gamer thinks that the first five clans of Bloodlines 2 are the right ones for a good start:
More information.
Thanks henriquejr!Bloodlines 2's first five clans are a perfect starting lineup
From abilities, politics, and popularity, Bloodlines 2 is starting off with the right clans.
Now that all five Bloodlines 2 clans have been revealed, we can all breath a collective sigh of relief knowing that most of our favorites are going to be in the game at launch. Paradox has mentioned that more clans will be added post-launch as DLCs, but we have a long time to wait until the game releases. Until then, we're free to speculate on what missing Camarilla clans and other clans might be added, but Paradox and Hardsuit Labs totally nailed its decision to start with these first five clans: Brujah, Toreador, Tremere, Ventrue, and Malkavian.
To simplify things, I won't be talking about the Thinbloods and their abilities. Even though they technically are a clan, you start off as one in Bloodlines 2, and you have new powers that did not appear in the first Bloodlines, so there is little comparison there. However, the five clans that I mentioned above provide a perfect, simplified platter of disciplines, personality, and playstyle options.
[...]
More information.