On my first play through eveything was fine except the Brood Mother wasn't available, so I never got the verbage for the final battle. So, I was forced to start completely over. I wasn't too tickled. (and yes, I was a good little boy, when I installed the game originaly, I closed open programs, shut off the virus checker…etc.)
On my 'load new game' game, here's what I was left with:
The stone/fire puzzle in the wending wood didn't work.
The 'trail of love' quest in the Blackmarch stopped at note number 5- I couldn't click on the stone.
I couldn't return the dead guy's wedding ring.
Of course, there is the grand lightning rune glitch at the keep.
Oghrens' 'family' quest was never presented to me.