E.Y.E: Divine Cybermancy is set in a dystopian future following a complex background of events. The human race has become involved in an interplanetary conflict stemming from a mysterious race as well as an unexplained psionic entity known as the meta-streumonic force, that has turned civilizations against each other and threatens the universe.
The player takes the role of an E.Y.E. member, a secretive and elite army of psi-cybernetic warrior monks founded, funded and ruled by a group of megacorporations named Secreta Secretorum. With access to advanced technology, each member is infused with cybernetics, psionic training, and DNA acquired from the only known member of the mysterious advanced civilization to ever be captured and killed.
The player wakes up after a fight in which your teammates are killed, with the Secreta Secretorum is attempting a coup against the all-powerful Federation, a consortium of corporations, several worlds and planets who comprise the current human government and rule them with an iron fist.
To complicate matters, E.Y.E is composed of two groups, the Jian Shang Di and the Culter Dei, to which you belong, both having their own leaders and members. Brothers in the past, they are currently in the middle of an unofficial and secret civil war. By the Year 15, this struggle has calmed down because their mutual fight against the Federation has intensified. However, in the shadows, Commander Rimanah plots to destabilize and destroy the Jians by weakening their power base or make them worthless in the eyes of Secreta Secretorum. He created a special task force for this goal, where the player is one of its members.
Your loyalties are torn between Commander Rimanah, (leader of the Culter Dei) who is a separatist with an unstoppable ambition, and your superior, and your Mentor, a friend and instructor. The Mentor tries at all costs to unite the two rival groups. In doing so, you are thrust into the middle of a fratricidal war frought with political conspiracies and quests for power in which different groups and megacorporations are implicated.
These troubles set the stage for an attack by the unknown meta-streumonic force bent on destroying humankind.