BioWare - A New Universe, ME's Universe to be Expanded in a New Way

According to Kotaku, Bioware is developing a totally new universe as well as a new ME 3 game:

For the new game, Casey Hudson, said this:

"We are developing a whole new fictional universe at BioWare for myself and Preston [and other main Mass Effect trilogy creators.] That's kind of our next thing," Husdon said. "We're focusing on building something new the way we did at the very beginning on Mass Effect.

For the new ME 3 game, Casey Hudson said this:

We want to be able to give fans an opportunity to get back into the world with these things you've come to know and love about the Mass Effect experience but start something fresh and new-a new way for you to explore the whole universe in Mass Effect."