There was also one game in the spelljammer setting - it was really, really bad.
Edit:
I also would love a hard scify RPG - without FTL-Travel, but with ships that can nearly fly with lightspeed, and with cyropreservation and transhumanism.
Yet another Edit:
I would love to see a Fantasy Setting wich considers the "special circumstances" of traditional non-human races:
If Elves are immortal, what would that mean for the different generations ? You would have to live with your great-great-grandfather who knew humans when they first crawled down from the trees ? There are nearly no female Dwarves… would that mean that only the most successful dwarves would get a bride ? would they live in a matriarchy ? would women be the most valuable possesion, sold for inconceivable amounts of money ? Orcs are mindlessly aggressiv… how can they still thrive ?