Breaking quests (SPOILER): First quest, Exam. I pick up the side quest for the miller, get thief clothes, talk to miller, and head towards the thieves in the swamp, handle that one disguised. Then, notice house on map, head there, talk to thieves there, and pay 'em 100 gold - blamo, you get a necklace and the "Go back to Don Mayshi" line - no explanation for the necklace (the quest previously mentioned rich landlords, but nothing about a necklace). If you then try to talk to the guy in the Inn, he'll just mutter something along the lines of "Oh, you again"... you also miss out on killing the Bald Magoo spies -- and maybe more, since I don't know how the "right" questline progresses (ditched that first playthrough when the spies slaughtered me). You can also somewhat break the miller quest - if you don't talk to the miller first, you won't get the reward from him (which is a decent 600 coins).