Some early impressions,
The UI is terrible, it's a straight port from console, can't even click stuff with the mouse sometimes, have to switch to the keyboard, it doesnt make sense. It's much worse than Oblivion.
The LOD is quite bad, i had hoped they would've improved this a lot since FO/NV, but they havent. It pops in instead of blending in smooth, so it's sometimes very visible how suddenly trees switches from 2D LOD's to real 3D meshes. Fortunately this can be changed in the .ini i believe - larger draw distance for the real meshes. The .ini is exactly like FO3/NV so its very configurable, which is great.
Loading times are short, takes me 15 sec from when i click the icon until i'm in-game playing. All games should be like this.. Havent noticed any stuttering whatsoever, so that's much better than FO:NV for example. Runs @ 60 FPS with everything maxed out, so no complaints there.
I like the animations for the most part, it feels like the bodies has weight to them. The swimming animation was nice too.. i dont care much for those kill "quick events", i like them in FO3 because of how brutal they can be, the animations for these in Skyrim arent that great, i can see how it could get a little annoying after a while.
There's a great feeling of adventure, much unlike Oblivion. Sometimes it feels a bit like Red Dead Redemption or maybe Gothic3, only better. GOTY without a doubt..