The Witcher 2 and Skyrim are two opposite poles within the RPG genre. Since I tend to value interesting NPCs, a good narrative, story and choices & consequences, I am more attracted to The Witcher than I am to a TES game.
I see Skyrim, though praise worthy in certain areas and not without merit, as a game where they clearly emphasised quantity over quality and my main initial worry was that CDPR might follow a similar route by claiming that they would create a world even bigger than that of Skyrim. It is simply madness to create such a large open world game while maintaining those qualities that make the Witcher series great. Although I wouldn't be surprised if that were to be simple PR talk and it doesn't make sense for them to depart too much from their game design strengths.
I would thus rather prefer a reduced scope in terms of size (in comparison to Skyrim) so that they can guarantee a certain level of quality and I also prefer the Gothic model in terms of open world design approach. They mentioned before the Gothic inspired lack of level scaling, which is a good thing indeed, and another thing that does reassure me is that the CDPR developers in the video seem to have a similar view on Skyrim as myself. They strongly praise the world exploration part, which I myself enjoyed a lot as well but they also criticise the generic and shallow nature of the quests and NPC's, which is completely in line with my own perception.
Another interesting thing is that they acknowledge the accomplishment of Fallout: New Vegas, which IMO is up until now the game most successful at combining open world aspects, narrative, C&C, etc., and they aim to surpass that game as well.
Despite the somewhat megalomaniac ambition of CDPR, I do have faith in them and it would indeed be an extraordinary feat if they are able to pull it off. Although I would very much be content with a "mere" 40-60 hour game with The Witcher style quality and replayability. Frankly speaking, I have no desire for 300 hours of epic genericness.