Looks interesting. I heard that it's really difficult even on the easier settings. What other roguelikes would you compare it to? If it's anything like SotS: The Pit then I'll definitely give it a try.
I don't play many roguelikes. In fact I've only played FTL before this one, but at it's core it's quite similar.
If you played FTL, you would remember a ship travelling to different sectors within which are different planets.
In DotE you will have a few characters travelling to different levels, within which are different rooms.
In FTL you build up your ship's capabilities with which you fight other ships, while in DotE you build up your characters' (up to 4) capabilities who fight enemies.
Inf FTL you manage resources such as Fuel, missiles and scrap to buy and shoot things, while in DotE you manage resources such as Dust (Gold), Food (XP and Health), Science (Research) and Production (Buldings).
In DotE you need to protect your crystal in your first room and then transport it to the last room.
Anyway, I suggest watching quill18's first video on it to get a good idea.
I died twice on level 2, once on level 3 and I finally got to level 5.
Hope that helps.