Interesting. For those who want to learn more, as I knew nothing about them:
https://pathfinderwiki.com/wiki/Rise_of_the_Runelords
From the idyllically peaceful coastal town of Sandpoint to an ancient lost city at the top of the world, Rise of the Runelords takes a party of adventurers from 1st to over 18th level and delves into the mysteries of Varisia's ancient past. Millennia ago, the powerful empire of Thassilon ruled the land, dominated by despotic runelords who maintained their power through harnessing the power of rune magic. Thought gone forever, the workings of Thassilon are not so far beneath the surface and one of the runelords plans a return to power. Only the brave adventurers stand in his way.
https://pathfinderwiki.com/wiki/Iron_Gods_(adventure_path)
Numeria has a long history of mystery and wonder buried under its rugged landscape, for on that one fateful night thousands of years ago, the Rain of Stars scarred the land. The fragmented remnants of a ship from beyond the stars fell from the sky, scattering strange technological ruins and deadly perils across the land. Today, these sites are feared by the barbaric tribes and coveted by the sinister spellcasters of the Technic League. Yet something worse than brutish berserker or super-science wizard has risen to power in these hidden technological halls. The Iron Gods are ready to make their presence known, and if they are not opposed by the region's newest heroes, a scourge unlike any the Inner Sea has seen will arise! From small Numerian towns to strange technological ruins to the region's infamous capital of Starfall—and perhaps beyond—the Iron Gods Adventure Path will take your heroes into places unlike any seen before in the Pathfinder Roleplaying Game!
https://pathfinderwiki.com/wiki/Skull_&_Shackles
There's adventure to be had on the high seas when a group of press-ganged strangers seizes a ship and becomes embroiled in the plots and politics of the Shackles—an infamous island chain dominated by pirate warlords. But as these new swashbucklers make names for themselves, rival scalawags, enemy navies, legendary sea monsters, and the infamous Hurricane King himself seek to see them walk the plank. Who will survive when there's glory to plunder?
Someone said anything but pirates earlier ... so guess third is out for them
For me, however, the third is the only one of interest. The first sounds like it has magic via runes and glyphs and I never liked that kind of magic although it does sound like it could be interesting.
While I didn't mind the technology in the WOTR area relating to Numeria I don't know if I would enjoy an entire game on it.
So somewhat leaves the third for me and I really enjoyed POE2 which was set on the islands. Course I was one of the few who enjoyed the boating aspect to travel as I know that seemed to be disliked or even hated by most.
I would probably like any game they made, however, if it was as good as their first two and based on the same universe.