I quite enjoyed watching that. I'm not sure where the isometric issue comes into play, I think the art style and platformy nature of the game looks great, especially combined with the wonderful music. It looks like an excellently reaslised worldbuild and atmosphere where nothing feels out of place.
What I would criticise would be:
Sound Effects: There's some really annoying sound effects that really jar with the music and atmosphere. The first and most annoying is the odd clicking-like noise that seems to be permanently clicking away while the guy moves about, that got irritating after just five minutes. The sound for looting the boxes seems to be about 3 different noises, all of which thump at you like a plank of wood to the head. Similarly the opening inventory noise is very meh. There seems to be no variety to the noise made in fights, it's all the same grunts and groans copy-pasted no matter who you're fighting or by what method.
General issues: Rain is good, but not for too long, it went on for too long in the clip. It seems like a bit of a sausage fest, as if women don't exist in this world beyond the odd random NPC, which is fine, but detracts from the believeability/immersion. He appeared to be just killing people willy nilly, there didn't seem to be any rhyme or reason to how and why the fights went as they did, as in group aggro and people just stopping fighting and going back to their 'position' too easily and just attacking people out the blue.
But, yeah, looked like it had the potential to be very fun.