Of course the loot that's dropped from combat is going to be random, but I think it's pretty obvious that's not what CelticFrost is talking about. He's talking about the loot in the game world. i.e. chests, closets, barrels, etc.
Loot dropped from enemies in a game where enemies sometime respawn has to be random for obvious reasons.
Loot dropped from enemies in a game where enemies sometime respawn has to be random for obvious reasons.