I don't know the ending yet and may not know what I'm asking, but I would be fine with the game happening in Night City again, some years later. Basically, pull the Yakuza thing of playing in the same city every game, with different towns/locations added as extra areas every game. Maybe the next game could be Night City + Crystal Palace, for instance, then Night City + someplace in Japan for the third, and so on. Night city is already HUGE, so we don't need big places.
Whatever the case, I hope we get to follow up on the Peralez quest. (That's the one where, in the end, you find out about a conspiracy that is taking over Mr. & Mrs. Paralez's minds and put a stop to it.)